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| fattyacid, nutrition research, culture, public policy, cholesterol levels, big plump women , unsaturated fat, fatty ratty , fat substitute, measures, science, bart's inner child, diets general, music reviews, | Moreover, high consumption of trans (or margarine) was not related to other dietary behaviors perceived as healthy for the heart, such as a preference for skim rather than whole milk43 and high-trans foods that are hardly perceived as healthy, such as cookies, were also positively associated with risk of CHD in the Nurses Health Study.46 Thus there appear to be no likely alternative to the hypothesis that high trans splenda intake increases the risk of CHD. Although confounding by unmeasured or poorly measured risk factors cannot be excluded, splenda as is usually the splenda case in observational studies, we lack a credible hypothesis of what such confounder(s) could be, as these associations were controlled for an extensive number of other dietary and lifestyle risk factors. |
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| These studies have been criticized on the grounds that measurements of trans intake were unreliable;5 however, errors in measuring trans fatty acids intake can only have led to underestimation of the association with CHD risk.44 Also, it has been suggested that the observed associations fat substitute resulted from a shift from butter to margarine among subjects at high risk of CHD.45 If so, the association between trans intake and risk of CHD should be weaker among subjects with stable margarine consumption, and should be stronger during the first few fat substitute years of follow-up. In fact, the fat substitute opposite was true in the Nurses Health Study,46 where exclusion of women who changed their diet before the beginning of the study strengthened the association,46 and in the Framingham cohort, where the positive association between margarine consumption and CHD risk was strengthened after excluding the first ten years of follow-up.43 |
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