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| fattyacid, nutrition research, culture, public policy, cholesterol levels, big plump women , unsaturated fat, fatty ratty , fat substitute, measures, science, bart's inner child, diets general, music reviews, | (95% confidence interval: 1.02, 2.28) and 1.44 (0.94, 2.20) respectively. In addition, there was significant heterogeneity in the odds ratios between countries, from 0.2 in Spain and Moscow, to 5.0 in Finland and 5.4 in Norway. This heterogeneity may be due andrew fox to different amounts, and sources of trans -- and therefore different isomers -- in different countries (for example in Spain, unlike in the other countries, andrew fox most dietary trans fatty andrew fox acids are from animal sources), or, more likely, to interaction with other dietary factors, or confounding by unmeasured or poorly measured covariates. Interpretation of the EURAMIC results is controversial, but in any case they do not provide strong evidence against the hypothesis that trans fatty acids increase the risk of CHD, and if anything add weight to the existence of a positive association. |
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| Investigations in which tissue or plasma fatty acids composition was used as a biomarker of trans intake29-36 gave conflicting results. With one exception,33 however, these investigations were small, and the power too low to reliably detect an association. unsaturated fat The only large study, the EURAMIC study,33 included 671 men with acute myocardial infarction in eight European countries. The overall analyses revealed no association between trans intake and risk of myocardial infarction (multivariate odds ratio comparing the top vs. the unsaturated fat bottom quartile was 0.97). The two centers in Spain, where CHD rates are very low, unsaturated fat however, had extremely low trans levels and little between-person variation compared to those from other countries, and thus provided little or no information on the relation between trans and CHD. After appropriately excluding these centers, the odds ratio in the third and fourth quartile increased to 1.53 |
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