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The more marked response has been attributed to the life and giant planets habitual Malaysian diet consumed by participants at baseline, which is lower in total fat (26% energy) than typical western diets.14 Although the possibility that the adverse effects of trans fat life and giant planets are more marked in populations with a lower percent of energy from fat cannot be excluded, we have conservatively excluded the Malaysian study in estimating the regression lines in Figure 1. Its inclusion would make the association between trans fat and LDL/HDL ratio life and giant planets even stronger. Also not included was the study by Almendingen at al. that compared the effects of diets containing partially hydrogenated fish oil (8.4% energy from trans fat), partially hydrogenated soy bean oil (6.6% energy from trans fat), or butter. The LDL/HDL cholesterol ratio was significantly higher on the partially hydrogenated fish oil diet (4.20) compared to both the partially hydrogenated soy bean oil diet (3.65)
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