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| so, trans fatty, food in, children's news, plump girls galleries , high risk, margarine, war on fat, low salt diet, children_s news online, omega 3 fatty acids, creatures, omega3 fatty acid , personals, fatty infiltration liver , diet industry, political forums, fatburning foods, foodfit, | "But saturated fats like palmitate plump sex are poorly stored in the tiny fat droplets plump sex normally found in most cells and therefore are more likely to enter into pathways that lead to cell death such as the one in which EF1A-1 is involved." In the process of identifying the role of EF1A-1, the lab members uncovered other proteins implicated in the toxicity of plump sex excess fats. They are now investigating each to find out what part it plays. Future investigations by Schaffer's research team will study the EF1A-1 protein to see whether fatty molecules directly alter the protein, or if they cause it to relocate within the cell. Borradaile NM, Buhman KK, Listenberger LL, Magee CJ, Morimoto ETA, Ory DS, Schaffer JE. A critical role for eukaryotic elongation factor 1A-1 in lipotoxic cell death. Molecular Biology of the Cell, February 2006. |
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| Schaffer's laboratory earlier had developed a transgenic mouse that accumulates fat in its heart muscle cells resulting in the death of cells, trans fatty heart failure and premature death. They found that EF1A-1 was increased nearly three-fold in the hearts of these animals. Removal of EF1A-1 protected cells from palmitate-induced death, and its absence allowed cells to withstand assault by highly trans fatty reactive oxygen molecules. According to study authors, this indicates that EF1A-1 probably contributes to cell death from oxidative stress, which trans fatty is known to stem from high lipid levels. Cytoskeletal changes seen in cells missing EF1A-1 suggested to the researchers that EF1A-1's cytoskeletal role also is important in cell death resulting from fat overload. "Cells have a lot of mechanisms for incorporating fatty acids into storage forms, for metabolizing them or for using them in cellular membranes," Schaffer says. |
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