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Not only did the CLA's impact on NF-kappa-B activity reduce the production of the COX-2 enzyme, but it also dampened the activity of any COX-2 that was made. "This is baffling," Cook told Science News Online, and suggests that CLA has at least two independent roles in tempering COX-2's overstimulation of inflammation. Studies fatty acids by other researchers have shown that a cow's diet can greatly influence her milk's CLA concentrations (see Why Grass Makes For Better Milk). Grass-fed cows tend to produce far fatty acids more fatty acids of the c9,t11 form, Cook notes, than do grain-fed animals. In contrast, grain feeding spurs more production of t10,c12 CLA. He now plans to work with animal scientists to investigate how much they can boost the t10,c12 in cow's milk.
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