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Fat-based substitutes derived from modifying length or number of fatty acids also seem to have no effect. These substitutes include caprenin and salatrim, as well as mono- and di-glycerides. Within the fat-based group, the safety research has focused primarily on nutritionfacts panel olestra, which may affect nutritional status by its effects on absorption of fat-soluble nutrients.7,15 In the gastrointestinal tract, fat-soluble nutrients can partially partition into olestra and be excreted.23 Factors that affect the level of partitioning include (1) the degree of fat solubility (the more fat soluble the nutrient, nutritionfacts panel the more it will be partitioned into olestra), (2) the relative amount of olestra to nutrient (partitioning increases as the amount of olestra per measure of nutrient increases), and (3) the timing of olestra and nutrient consumption (partitioning can occur when olestra and the fat-soluble nutrients are in the gut at the same time).
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