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Overweight and obese individuals were more likely to be olestra users than were normal-weight individuals, but having diabetes was negatively associated with olestra use. In a double-blind, placebo-controlled, within-subject crossover study, 20 to 35 g of olestra was covertly substituted for conventional fat, mary enig and subjects had ad libitum access to additional fat, which allowed the investigators to determine if the replacement of conventional fat mary enig with a substitute would reduce fat and energy intake.12 During the 2 weeks of olestra feeding, subjects consumed 8% less total energy and had an 11% lower intake mary enig of fat than during the 2-week conventional fat feeding period. The total deficit achieved with the substitution was only 2616 kcal over the 14-day study period.12 In a single-meal feeding study, substituting olestra for regular fat reduced intake by 450 kcal, but neither the participants subjective ratings of postmeal hunger nor the amount of food consumed during the subsequent meal changed.22
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