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Moreover, these effects of trans fat on the LDL/HDL cholesterol ratio are remarkably constant across studies. The only somewhat discordant result was obtained by Sundram et al. anabolism among 27 men and women who were staff of the anabolism Palm Oil Research Institute in Malaysia.14 In that study, the effect of trans fat on the LDL/HDL cholesterol ratio was considerably stronger than in the other investigations (see Figure 1), anabolism whereas little effect was seen for saturated fat (palmitic acid). The more marked response has been attributed to the habitual Malaysian diet consumed by participants at baseline, which is lower in total fat (26% energy) than typical western diets.14 Although the possibility that the adverse effects of trans fat are more marked in populations with a lower percent of energy from fat cannot be excluded, we have conservatively excluded the Malaysian study in estimating the regression lines in Figure 1.
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