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but nothing significant. If there was any effect, it was "consistent with alcohol the small-to-negligible effect predicted by metabolic studies." Another way of putting it: No big deal. On total fat and cholesterol intake there was no significant relation to intake and CHD. Indeed, a 1998 review alcohol in the Journal of Clinical Epidemiology of the low fat-cholesterol-CHD thesis found that out of a total of 27 studies involving alcohol more than 150,000 subjects, in only three cohorts did patients with CHD consume more fat than the controls. In one cohort, those with cardiovascular disease actually consumed less fat than the controls. In all of the remaining cohorts, there was no statistically significant difference in fat consumption between those who had CVD and those who did not. And a very large study of 28,000 Swedes -- the Malmö Diet and Cancer Study -- published just last year in the Journal of Internal Medicine noted: "Over the last decades evidence from large-scale epidemiological studies has been emerging, partly defying the previously believed hypotheses, with voices rejecting the fat-disease hypotheses becoming more prominent."
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