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Free fatty acids are an important source of fuel for many tissues since they can yield relatively large quantities of ATP. Many cell types can use either glucose or fatty acids for this purpose. However, heart and skeletal muscle prefer fatty acids. On the other hand, the brain cannot use fatty acids as a source of fuel, relying calculators instead on glucose, or on ketone bodies produced by the liver from fatty acid metabolism calculators during starvation, calculators or periods of low carbohydrate intake. [edit] pH Formic acid and acetic acid are miscible with water and dissociate to form reasonably strong acids (pKa respectively 3.77 and 4.76). Longer chain fatty acids do not show a great change in pKa: nonanic acid, for example, has a pKa of 4.96. However, as the chain length increases the solubility of the fatty acids in water decreases very rapidly, so that the longer chain fatty acids have very little effect on the pH of a solution. The significance of their pKa values therefore only has relevance to the types of reaction that they take part in.
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