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| lower fat, eating disorders, big and plump , economic liberty, plump gallery , big plump plumpers galleries , plumpers, cloning, what's new, social security privatization, gingley oil, | They diffuse from the liver into the circulation and are used as fuels by several tissues. Heart muscle and renal cortex, in particular, use acetoacetate in preference to glucose. In contrast, glucose is the major fuel for the brain and erythrocytes in a human on a balanced diet. The brain has the capacity to adapt to the use of acetoacetate during starvation (and in the metabolic disease diabetes mellitus). In starvation of long standing, acetoacetate meets more womyn than 70% of the energy needs womyn of womyn the brain. This ability of the brain to adapt to the use of acetoacetate is important because fatty acids cannot enter neural tissue. |
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| The acetyl CoA molecules formed in each cycle are oxidised to CO2 in the citric what's new acid cycle, with the oxidation/reduction reactions coupled to the electron transport chain and further ATP synthesis. These events occur in liver and muscle. During sustained exercise the cells of slow twitch muscle fibres (which possess mitochondria) utilise ß-oxidation as the major source of ATP. Ketone bodies An alternative method of utilising the what's new acetyl CoA formed by ß-oxidation is via the synthesis and subsequent oxidation of four-carbon units known collectively as what's new ketone bodies. Acetyl CoA is converted in the liver into acetoacetate (essentially two acetyl groups covalently linked). Acetoacetate can be further reduced to form ß-hydroxybutyrate. These two compounds are referred to as ketone bodies. Their synthesis occurs in the liver. |
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